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KMID : 0376119930200020257
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Medical Journal of the Red Cross Hospital
1993 Volume.20 No. 2 p.257 ~ p.262
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Effect of Labetalol on the Hemodynamic Response to Endotracheal Intubation
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이호연
임청현/이승림/김홍렬
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Abstract
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Endotracheal intubation following anesthesia induction frequently produces hypertension and tachycardia. This study evaluated the efficacy of preinduction IV labetalol for attenuating the hemodynamic responses to intubation following thiopental
and
succinylcholine induction of anesthesia. Forty adult patients were devided into two gorups of 20 each; placebo(saline), labetalol 0.3mg/kg. The preparation was administered as an IV bolus 3 minutes prior to induction. Heart rate and blood
pressure
wee
measured upon arrival in the operating room (baseline), at 3 minutes after labetalol or placebo administration, immediately before intubation, immediately after intubation, 1 minute after intubation and at 2, 3, 5, 7, 10 minutes after intubation.
Labetalol 0.3 mg/kg IV prevented a rise in heart rate after intubation compared to patients who received placebo. The hypertensive response to intubation was similar in two groups. Labetalol 0.3 mg/kg IV just prior to induction of anesthesia is a
safe
and cost-effective means of preventing tachycardia but not hypertension in response to laryngoscopy and endotracheal intubation.
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